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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733096
Species: Mus musculus
RGD Object: Gene
Symbol: Hmbs
Name: hydroxymethylbilane synthase
Acc ID: CHEBI:18135
Term: catechol
Definition: A benzenediol comprising of a benzene core carrying two hydroxy substituents ortho to each other.
Chemical ID: MESH:C034221
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmbsdecreases methylationISOHMBS (Homo sapiens)6480464CTDcatechol results in decreased methylation of HMBS promoterPMID:23022512
Hmbsincreases expressionISOHMBS (Homo sapiens)6480464CTDcatechol results in increased expression of HMBS mRNAPMID:23022512 PMID:28552822
Hmbsincreases methylationISOHMBS (Homo sapiens)6480464CTDcatechol results in increased methylation of HMBS exonPMID:28552822
Hmbsmultiple interactionsISOHMBS (Homo sapiens)6480464CTD[catechol co-treated with Hemin] results in increased expression of HMBS mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA]; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA]; catechol promotes the reaction [Hemin results in increased expression of HMBS mRNA]; COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of HMBS mRNA]; Hemin promotes the reaction [catechol results in increased expression of HMBS mRNA]PMID:24141029 PMID:28552822
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