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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732334
Species: Homo sapiens
RGD Object: Gene
Symbol: TYMS
Name: thymidylate synthetase
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TYMSaffects expressionEXP 6480464CTDCisplatin affects the expression of TYMS mRNAPMID:23300844
TYMSdecreases degradationEXP 6480464CTDCisplatin results in decreased degradation of TYMS proteinPMID:21444628
TYMSdecreases response to substanceEXP 6480464CTDTYMS protein results in decreased susceptibility to CisplatinPMID:21444628
TYMSincreases activityEXP 6480464CTDCisplatin results in increased activity of TYMS proteinPMID:16568373
TYMSincreases expressionEXP 6480464CTDCisplatin results in increased expression of TYMS mRNAPMID:16568373 PMID:21444628 PMID:27392435
TYMSincreases stabilityEXP 6480464CTDCisplatin results in increased stability of TYMS mRNAPMID:21444628
TYMSmultiple interactionsEXP 6480464CTD[Cisplatin co-treated with Fluorouracil] results in decreased expression of TYMS mRNA; [Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMS protein; acetylleucyl-leucyl-norleucinal inhibits the reaction [[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMS protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMS protein]; PCNA mRNA affects the reaction [TYMS mRNA affects the susceptibility to Cisplatin]; TYMS gene polymorphism results in decreased susceptibility to [Fluorouracil co-treated with Cisplatin]; TYMS gene polymorphism results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Cisplatin co-treated with Paclitaxel]; U 0126 inhibits the reaction [Cisplatin results in decreased degradation of TYMS protein]PMID:15737843 PMID:16424979 PMID:16622263 PMID:16685392 PMID:21444628
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