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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732160
Species: Mus musculus
RGD Object: Gene
Symbol: Pdcd4
Name: programmed cell death 4
Acc ID: CHEBI:9168
Term: sirolimus
Definition: A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.
Chemical ID: MESH:D020123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pdcd4increases expressionEXP 6480464CTDSirolimus results in increased expression of PDCD4 proteinPMID:26369790
Pdcd4increases stabilityEXP 6480464CTDSirolimus results in increased stability of PDCD4 proteinPMID:24304514
Pdcd4multiple interactionsEXP 6480464CTD[Sirolimus co-treated with resveratrol] results in increased stability of PDCD4 protein; PDCD4 mutant form inhibits the reaction [Sirolimus inhibits the reaction [Pasteurella multocida toxin results in increased expression of CTSK mRNA]]; Sirolimus inhibits the reaction [Pasteurella multocida toxin results in decreased expression of PDCD4 mRNA]; Sirolimus inhibits the reaction [Pasteurella multocida toxin results in decreased expression of PDCD4 protein]; TSC2 gene mutant form promotes the reaction [[Sirolimus co-treated with resveratrol] results in increased stability of PDCD4 protein]PMID:24304514 PMID:26369790
Pdcd4increases expressionISOPDCD4 (Homo sapiens)6480464CTDSirolimus results in increased expression of PDCD4 mRNA; Sirolimus results in increased expression of PDCD4 proteinPMID:17259349 PMID:24356939
Pdcd4increases stabilityISOPdcd4 (Rattus norvegicus)6480464CTDSirolimus results in increased stability of PDCD4 proteinPMID:24304514
Pdcd4increases stabilityISOPDCD4 (Homo sapiens)6480464CTDSirolimus results in increased stability of PDCD4 proteinPMID:24304514
Pdcd4multiple interactionsISOPdcd4 (Rattus norvegicus)6480464CTDresveratrol inhibits the reaction [Sirolimus results in increased stability of PDCD4 protein]PMID:24304514
Pdcd4multiple interactionsISOPDCD4 (Homo sapiens)6480464CTD[resveratrol co-treated with Sirolimus] results in increased stability of PDCD4 protein; Sirolimus promotes the reaction [Tretinoin results in increased expression of PDCD4 protein]PMID:17259349 PMID:24304514
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