GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CACNA2D1 | affects binding | ISO | Cacna2d1 (Mus musculus) | 6480464 | CTD | gabapentin binds to CACNA2D1 protein | PMID:16380257 | CACNA2D1 | affects binding | ISO | Cacna2d1 (Rattus norvegicus) | 6480464 | CTD | gabapentin binds to CACNA2D1 protein | PMID:16380257 | CACNA2D1 | multiple interactions | ISO | Cacna2d1 (Mus musculus) | 6480464 | CTD | [gabapentin binds to and results in decreased activity of CACNA2D1 protein] which results in decreased susceptibility to Methamphetamine; [gabapentin binds to and results in decreased activity of CACNA2D1 protein] which results in decreased susceptibility to Potassium Chloride; [gabapentin results in decreased activity of CACNA2D1 protein] inhibits the reaction [Potassium Chloride results in increased transport of Calcium]; gabapentin inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 mRNA] | PMID:17442347 PMID:17881535 PMID:20340177 PMID:21182903 | CACNA2D1 | multiple interactions | ISO | Cacna2d1 (Rattus norvegicus) | 6480464 | CTD | CACNA2D1 protein results in increased susceptibility to [gabapentin affects the activity of [CACNA1D protein co-treated with CACNB3 protein]] | PMID:19796812 | | ||||||||||||||||||||||
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