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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730973
Species: Mus musculus
RGD Object: Gene
Symbol: Srebf2
Name: sterol regulatory element binding factor 2
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Srebf2increases expressionEXP 6480464CTDStreptozocin results in increased expression of SREBF2 mRNA; Streptozocin results in increased expression of SREBF2 proteinPMID:29420703 PMID:34896238
Srebf2multiple interactionsEXP 6480464CTDAcrylamide inhibits the reaction [Streptozocin results in increased expression of SREBF2 mRNA]; fatostatin inhibits the reaction [Streptozocin results in increased expression of SREBF2 protein]PMID:29420703 PMID:34896238
Srebf2increases expressionISOSrebf2 (Rattus norvegicus)6480464CTDStreptozocin results in increased expression of SREBF2 mRNA; Streptozocin results in increased expression of SREBF2 proteinPMID:23647015
Srebf2multiple interactionsISOSrebf2 (Rattus norvegicus)6480464CTD[[Dietary Fats co-treated with Carbamazepine] affects the susceptibility to Streptozocin] which results in decreased expression of SREBF2 mRNA; [[Streptozocin co-treated with Carbamazepine] affects the susceptibility to Dietary Fats] which results in decreased expression of SREBF2 mRNA; [Dietary Fats co-treated with Streptozocin co-treated with Carbamazepine] results in decreased expression of SREBF2 mRNA; [Streptozocin co-treated with Cadmium] results in increased expression of SREBF2 protein; Allopurinol inhibits the reaction [Streptozocin results in increased expression of SREBF2 mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of SREBF2 protein]; myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in increased expression of SREBF2 protein]; Quercetin inhibits the reaction [Streptozocin results in increased expression of SREBF2 mRNA]; Quercetin inhibits the reaction [Streptozocin results in increased expression of SREBF2 protein]PMID:23647015 PMID:25240712 PMID:35786680
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