GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Srebf2 | increases expression | ISO | Srebf2 (Rattus norvegicus) | 6480464 | CTD | Simvastatin results in increased expression of SREBF2 mRNA | PMID:12056585 | Srebf2 | increases expression | ISO | SREBF2 (Homo sapiens) | 6480464 | CTD | Simvastatin results in increased expression of SREBF2 protein modified form | PMID:20018177 | Srebf2 | multiple interactions | ISO | Srebf2 (Rattus norvegicus) | 6480464 | CTD | Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of SREBF2 mRNA]; Simvastatin results in increased activity of and results in increased localization of SREBF2 protein | PMID:12056585 | Srebf2 | multiple interactions | ISO | SREBF2 (Homo sapiens) | 6480464 | CTD | Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [SREBF2 protein binds to PON1 promoter]]; Simvastatin promotes the reaction [SREBF2 protein binds to PON1 promoter] | PMID:14500290 | |
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