GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Srebf2 | increases abundance | ISO | SREBF2 (Homo sapiens) | 6480464 | CTD | SREBF2 protein results in increased abundance of Cholesterol | PMID:33677747 | Srebf2 | multiple interactions | ISO | Srebf2 (Rattus norvegicus) | 6480464 | CTD | [Cholesterol deficiency co-treated with Lovastatin] results in increased activity of SREBF2 protein; Cholesterol inhibits the reaction [[Cholesterol deficiency co-treated with Lovastatin] results in increased activity of SREBF2 protein] | PMID:20578043 | Srebf2 | multiple interactions | ISO | SREBF2 (Homo sapiens) | 6480464 | CTD | [25-hydroxycholesterol co-treated with Cholesterol] results in decreased cleavage of SREBF2 protein; [[Troglitazone binds to and results in increased activity of PPARG protein] which results in decreased expression of SREBF2 protein] which results in decreased abundance of Cholesterol; betadex inhibits the reaction [SREBF2 protein results in increased abundance of Cholesterol]; SREBF2 promotes the reaction [bisphenol A results in increased import of Cholesterol]; SREBF2 protein affects the reaction [Lipopolysaccharides results in increased abundance of Cholesterol] | PMID:16946405 PMID:27324795 PMID:28057006 PMID:33677747 | | ||||||||||||||||||||||
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