GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | HIF1A | affects activity | EXP | | 6480464 | CTD | Cisplatin affects the activity of HIF1A protein | PMID:25596134 | HIF1A | affects localization | EXP | | 6480464 | CTD | Cisplatin affects the localization of HIF1A protein | PMID:17066447 PMID:20935474 | HIF1A | affects response to substance | EXP | | 6480464 | CTD | HIF1A affects the susceptibility to Cisplatin; HIF1A protein affects the susceptibility to Cisplatin | PMID:16532342 PMID:21964646 | HIF1A | decreases activity | EXP | | 6480464 | CTD | Cisplatin results in decreased activity of HIF1A protein | PMID:17498666 | HIF1A | decreases expression | EXP | | 6480464 | CTD | Cisplatin results in decreased expression of HIF1A mRNA; Cisplatin results in decreased expression of HIF1A protein | PMID:17498666 PMID:25450742 PMID:29690507 | HIF1A | decreases response to substance | EXP | | 6480464 | CTD | Cisplatin results in decreased susceptibility to HIF1A protein | PMID:17066447 | HIF1A | decreases uptake | EXP | | 6480464 | CTD | HIF1A protein results in decreased uptake of Cisplatin | PMID:17066447 | HIF1A | increases degradation | EXP | | 6480464 | CTD | Cisplatin results in increased degradation of HIF1A protein | PMID:17498666 | HIF1A | increases expression | EXP | | 6480464 | CTD | Cisplatin results in increased expression of HIF1A protein | PMID:21674241 | HIF1A | multiple interactions | EXP | | 6480464 | CTD | ABCB1 affects the reaction [HIF1A affects the susceptibility to Cisplatin]; ABCC1 affects the reaction [HIF1A affects the susceptibility to Cisplatin]; Acetylcysteine inhibits the reaction [Cisplatin affects the localization of HIF1A protein]; Cisplatin inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein]; Cisplatin inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]; Cisplatin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Cisplatin promotes the reaction [HIF1A protein binds to VEGFA promoter]; Cyclosporine inhibits the reaction [HIF1A protein results in decreased uptake of Cisplatin]; HIF1A protein affects the reaction [Cisplatin results in increased expression of FTL protein]; Oxygen deficiency inhibits the reaction [Cisplatin results in decreased expression of HIF1A protein]; Topotecan inhibits the reaction [Cisplatin affects the localization of HIF1A protein]; Topotecan inhibits the reaction [Cisplatin promotes the reaction [HIF1A protein binds to VEGFA promoter]]; TP53 protein affects the reaction [Cisplatin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; TP53 protein affects the reaction [Cisplatin results in increased degradation of HIF1A protein] | PMID:11090055 PMID:17066447 PMID:17498666 PMID:20935474 PMID:21964646 PMID:29690507 PMID:33969609 | HIF1A | decreases expression | ISO | Hif1a (Mus musculus) | 6480464 | CTD | Cisplatin results in decreased expression of HIF1A mRNA | PMID:29148169 | HIF1A | increases expression | ISO | Hif1a (Rattus norvegicus) | 6480464 | CTD | Cisplatin results in increased expression of HIF1A mRNA; Cisplatin results in increased expression of HIF1A protein | PMID:18656965 PMID:25598344 | HIF1A | multiple interactions | ISO | Hif1a (Rattus norvegicus) | 6480464 | CTD | saponin Rb1, Panax notoginsenoside promotes the reaction [Cisplatin results in increased expression of HIF1A protein] | PMID:25598344 | |
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