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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727948
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppargc1b
Name: PPARG coactivator 1 beta
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargc1bdecreases expressionEXP 6480464CTDEstradiol results in decreased expression of PPARGC1B mRNAPMID:20068009
Ppargc1bincreases expressionISOPPARGC1B (Homo sapiens)6480464CTDEstradiol results in increased expression of PPARGC1B mRNAPMID:23019147 PMID:31614463 PMID:36828454
Ppargc1bmultiple interactionsISOPPARGC1B (Homo sapiens)6480464CTDEstradiol promotes the reaction [ESR1 protein binds to PPARGC1B protein]PMID:29389661
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