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GENE - TERM ANNOTATION REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: GO:0000165
Term: MAPK cascade
Definition: An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
Definition Source(s): PMID:20811974, PMID:9561267
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1 IMP 1626216RGD  
Mapk1acts_upstream_of_or_withinISOMapk1 (Mus musculus)1624291RGD PMID:8626447 PMID:9064344 PMID:9254656

PMID:8626447 PMID:9064344 PMID:9254656
Mapk1involved_inISOMapk1 (Mus musculus)1624291RGDMGI:1346859 PMID:21220101

PMID:21220101
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