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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:8364
Term: prazosin
Definition: A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
Chemical ID: MESH:D011224
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1affects activityEXP 6480464CTDPrazosin affects the activity of MAPK1 proteinPMID:11693273
Mapk1multiple interactionsEXP 6480464CTDPrazosin affects the reaction [Norepinephrine results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Prazosin inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]PMID:11880281 PMID:12513686 PMID:18445782 PMID:20434527
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTDPrazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]PMID:11804996 PMID:17306214
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