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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1multiple interactionsEXP 6480464CTDochratoxin A results in increased phosphorylation of and results in increased activity of MAPK1 proteinPMID:11711124 PMID:17651772
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDochratoxin A results in increased phosphorylation of MAPK1 proteinPMID:22230261 PMID:25002221 PMID:27193732 PMID:29673704 PMID:31154016
Mapk1increases phosphorylationISOMapk1 (Mus musculus)6480464CTDochratoxin A results in increased phosphorylation of MAPK1 proteinPMID:23172667
Mapk1increases response to substanceISOMAPK1 (Homo sapiens)6480464CTDMAPK1 protein results in increased susceptibility to ochratoxin APMID:22230261
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ochratoxin A results in increased phosphorylation of MAPK1 protein]; Citrinin promotes the reaction [ochratoxin A results in increased phosphorylation of MAPK1 protein]; MAPK1 protein promotes the reaction [ochratoxin A inhibits the reaction [CDK1 protein binds to CCNB1 protein]]; MAPK1 protein promotes the reaction [ochratoxin A results in decreased expression of CCNB1 protein]; MAPK1 protein promotes the reaction [ochratoxin A results in decreased expression of CDC25C protein modified form]; MAPK1 protein promotes the reaction [ochratoxin A results in decreased expression of CDC25C protein]; MAPK1 protein promotes the reaction [ochratoxin A results in decreased expression of CDK1 protein modified form]; MAPK1 protein promotes the reaction [ochratoxin A results in decreased expression of CDK1 protein]; ochratoxin A promotes the reaction [Citrinin results in increased phosphorylation of MAPK1 protein]; ochratoxin A results in increased phosphorylation of and results in increased activity of MAPK1 protein; wortmannin promotes the reaction [ochratoxin A results in increased phosphorylation of MAPK1 protein]PMID:11711124 PMID:22230261 PMID:25002221 PMID:29673704
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