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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:5132
Term: flutamide
Definition: A (trifluoromethyl)benzene that has formula C11H11F3N2O3.
Chemical ID: MESH:D005485
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases expressionEXP 6480464CTDFlutamide results in increased expression of MAPK1 mRNA; Flutamide results in increased expression of MAPK1 proteinPMID:24136188 PMID:26437446
Mapk1multiple interactionsEXP 6480464CTDFlutamide inhibits the reaction [[bisphenol A co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]PMID:30707916
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