GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mapk1 | decreases phosphorylation | EXP | | 6480464 | CTD | Curcumin results in decreased phosphorylation of MAPK1 protein | PMID:17965732 PMID:18332871 | Mapk1 | multiple interactions | EXP | | 6480464 | CTD | Curcumin inhibits the reaction [Corticosterone results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Fructose results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK1 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; tin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]] | PMID:11981161 PMID:16934299 PMID:17372590 PMID:18784349 PMID:19175364 PMID:26713546 PMID:29723552 | Mapk1 | decreases activity | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | Curcumin results in decreased activity of MAPK1 protein | PMID:21493726 | Mapk1 | decreases expression | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | Curcumin results in decreased expression of MAPK1 protein | PMID:18555241 | Mapk1 | decreases phosphorylation | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | Curcumin results in decreased phosphorylation of MAPK1 protein | PMID:19383353 | Mapk1 | decreases phosphorylation | ISO | Mapk1 (Mus musculus) | 6480464 | CTD | Curcumin results in decreased phosphorylation of MAPK1 protein | PMID:34272803 | Mapk1 | increases phosphorylation | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | Curcumin results in increased phosphorylation of MAPK1 protein | PMID:18316600 PMID:34634291 | Mapk1 | increases phosphorylation | ISO | Mapk1 (Mus musculus) | 6480464 | CTD | Curcumin results in increased phosphorylation of MAPK1 protein | PMID:17535857 | Mapk1 | multiple interactions | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; [Curcumin results in decreased activity of MAPK1 protein] which results in increased susceptibility to Cisplatin; [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of MAPK1 protein; Acetylcysteine inhibits the reaction [Curcumin results in increased phosphorylation of MAPK1 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Bortezomib promotes the reaction [Curcumin results in decreased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Acids results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [bromopyruvate results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [cadmium sulfate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Furazolidone results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; Curcumin results in increased phosphorylation of and results in increased activity of MAPK1 protein; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]; MAPK1 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA]; rottlerin inhibits the reaction [Curcumin results in increased expression of MAPK1 protein]; U 0126 inhibits the reaction [Curcumin results in increased phosphorylation of MAPK1 protein]; U 0126 promotes the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]] | PMID:18214481 PMID:18316600 PMID:18357586 PMID:19074641 PMID:19383353 PMID:20605902 PMID:20727180 PMID:21493726 PMID:21810436 PMID:22142850 PMID:24307199 PMID:25866362 PMID:27996348 PMID:34634291 PMID:35752269 | Mapk1 | multiple interactions | ISO | Mapk1 (Mus musculus) | 6480464 | CTD | [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; [piperlongumine co-treated with Curcumin] results in decreased activity of MAPK1 protein; Curcumin inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of MAPK1 protein] | PMID:11035063 PMID:18321868 PMID:19501152 PMID:26191140 PMID:31081568 PMID:33617879 PMID:34272803 | | ||||||||||||||||||||||
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