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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:38957
Term: 4,4'-thiodiphenol
Definition: A phenol that has formula C12H10O2S.
Chemical ID: MESH:C586730
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDbis(4-oxyphenyl)sulfide results in increased phosphorylation of MAPK1 proteinPMID:27880919
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased phosphorylation of MAPK1 protein]PMID:27880919
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