GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mapk1 | increases phosphorylation | EXP | | 6480464 | CTD | cobaltous chloride results in increased phosphorylation of MAPK1 protein | PMID:22134701 PMID:31472278 | Mapk1 | increases response to substance | EXP | | 6480464 | CTD | MAPK1 protein results in increased susceptibility to cobaltous chloride | PMID:21998720 | Mapk1 | multiple interactions | EXP | | 6480464 | CTD | [cobaltous chloride results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; Acetylcysteine inhibits the reaction [[cobaltous chloride results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide inhibits the reaction [cobaltous chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; cobaltous chloride inhibits the reaction [Methylprednisolone results in decreased expression of MAPK1 protein modified form]; cobaltous chloride inhibits the reaction [Methylprednisolone results in decreased phosphorylation of MAPK1 protein]; cobaltous chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein; iodopravadoline inhibits the reaction [cobaltous chloride results in increased phosphorylation of MAPK1 protein]; PRKCE protein promotes the reaction [cobaltous chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; sodium bisulfide inhibits the reaction [[cobaltous chloride results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; sodium bisulfide inhibits the reaction [cobaltous chloride results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [cobaltous chloride results in increased phosphorylation of MAPK1 protein]; Zinc inhibits the reaction [cobaltous chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein] | PMID:12904460 PMID:18375950 PMID:21998720 PMID:22134701 PMID:31472278 | Mapk1 | increases phosphorylation | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | cobaltous chloride results in increased phosphorylation of MAPK1 protein | PMID:17640750 PMID:19101624 PMID:20452389 PMID:27297870 PMID:29165873 | Mapk1 | increases phosphorylation | ISO | Mapk1 (Mus musculus) | 6480464 | CTD | cobaltous chloride results in increased phosphorylation of MAPK1 protein | PMID:16507596 | Mapk1 | multiple interactions | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAP2K1 protein] inhibits the reaction [cobaltous chloride results in increased activity of [MAPK1 protein co-treated with MAPK3 protein]]; cobaltous chloride results in increased activity of [MAPK1 protein co-treated with MAPK3 protein]; U 0126 inhibits the reaction [cobaltous chloride results in increased phosphorylation of MAPK1 protein] | PMID:14536030 PMID:20452389 | | ||||||||||||||||||||||
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