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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of MAPK1 mRNA; Benzo(a)pyrene results in decreased expression of MAPK1 protein modified formPMID:25233930 PMID:32255272
Mapk1decreases phosphorylationEXP 6480464CTDBenzo(a)pyrene results in decreased phosphorylation of MAPK1 proteinPMID:32255272
Mapk1increases phosphorylationEXP 6480464CTDBenzo(a)pyrene results in increased phosphorylation of MAPK1 proteinPMID:16456883 PMID:22348481 PMID:34999049
Mapk1multiple interactionsEXP 6480464CTD[IL27 protein co-treated with IFNL3 protein] inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; Benzo(a)pyrene inhibits the reaction [TNF protein results in increased expression of MAPK1 protein modified form]; IFNL3 protein inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; IL27 protein inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; sodium arsenite promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]PMID:16456883 PMID:25233930 PMID:34999049
Mapk1decreases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased phosphorylation of MAPK1 proteinPMID:24685774
Mapk1increases activityISOMAPK1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased activity of MAPK1 proteinPMID:15792794
Mapk1increases expressionISOMapk1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of MAPK1 mRNAPMID:22228805
Mapk1increases methylationISOMAPK1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of MAPK1 promoterPMID:27901495
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased phosphorylation of MAPK1 proteinPMID:20840854 PMID:23228475 PMID:25724548 PMID:26359795 PMID:29545172 PMID:30236600 PMID:32062438 PMID:33393179 PMID:33421718
Mapk1increases phosphorylationISOMapk1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased phosphorylation of MAPK1 proteinPMID:18321868 PMID:19041363 PMID:19874837 PMID:25724548 PMID:33393179
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD2,4,4'-trichlorobiphenyl inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; 2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; 2,4,5,2',5'-pentachlorobiphenyl inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; 3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAPK1 protein; [sodium arsenite results in increased abundance of Arsenic] promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; AHR protein promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; alizarin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; Benzo(a)pyrene inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; Benzo(a)pyrene promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK1 protein]; Benzo(a)pyrene results in increased phosphorylation of and results in increased activity of MAPK1 protein; Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAPK1 protein]; Dasatinib inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; MAPK1 protein affects the reaction [Benzo(a)pyrene results in increased expression of MUC5AC mRNA]; MAPK1 protein affects the reaction [Benzo(a)pyrene results in increased expression of MUC5AC protein]; MitoTEMPO inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; pinocembrin promotes the reaction [Dasatinib inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]]; pyrazolanthrone inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; Resveratrol inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; SOCS3 protein inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]]; SOCS3 protein inhibits the reaction [Benzo(a)pyrene promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK1 protein]]; StemRegenin 1 inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; U 0126 affects the reaction [Benzo(a)pyrene results in decreased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]PMID:20840854 PMID:20876236 PMID:21882252 PMID:24685774 PMID:25724548 PMID:26359795 PMID:29545172 PMID:32062438 PMID:33393179 PMID:33421718 PMID:34329126
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTD[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAPK1 protein; Acetylcysteine inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; Benzo(a)pyrene results in increased phosphorylation of and results in increased activity of MAPK1 protein; Chlordan promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]PMID:12213569 PMID:18321868 PMID:19874837 PMID:25724548 PMID:32062438 PMID:33393179
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