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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:29699
Term: tunicamycin
Definition: A mixture of antiviral nucleoside antibiotics produced by Streptomyces lysosuperificus. It contains at least 10 homologues comprising uracil, N-acetylglucosamine, an 11-carbon aminodialdose called tunicamine, and a fatty acid linked to the amino group of the tunicamine. The homologues vary in the composition of the fatty acid moiety.
Chemical ID: MESH:D014415
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases phosphorylationEXP 6480464CTDTunicamycin results in increased phosphorylation of MAPK1 proteinPMID:21147958
Mapk1decreases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDTunicamycin results in decreased phosphorylation of MAPK1 proteinPMID:36509116
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTDArsenic Trioxide inhibits the reaction [Tunicamycin results in decreased phosphorylation of MAPK1 protein]PMID:36509116
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTD[Tunicamycin co-treated with HRAS protein] results in decreased phosphorylation of MAPK1 proteinPMID:24898257
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