GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mapk1 | increases phosphorylation | EXP | | 6480464 | CTD | Acetylcysteine results in increased phosphorylation of MAPK1 protein | PMID:16983658 | Mapk1 | multiple interactions | EXP | | 6480464 | CTD | Acetylcysteine affects the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [[cobaltous chloride results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Acetaldehyde results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [aureusidin results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [cadmium sulfate results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Ditiocarb results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Ethanol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of MAPK1 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in decreased expression of and results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [NGF protein results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Nickel analog promotes the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [pyrrolidine dithiocarbamic acid results in decreased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [raiser results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Acetylcysteine results in increased phosphorylation of MAPK1 protein] | PMID:10658192 PMID:12065697 PMID:12717738 PMID:15228596 PMID:15252869 PMID:16261333 PMID:16603213 PMID:16983658 PMID:17645304 PMID:18375950 PMID:18629305 PMID:18703135 PMID:19038359 PMID:21145380 PMID:21998720 PMID:22085843 PMID:22134701 PMID:22700867 PMID:22767315 PMID:23405080 PMID:23577223 PMID:23774252 PMID:23876460 PMID:24401988 PMID:29087013 PMID:29248592 PMID:31790703 PMID:36813253 PMID:8616849 | Mapk1 | decreases phosphorylation | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | Acetylcysteine results in decreased phosphorylation of MAPK1 protein | PMID:12690112 PMID:34520753 | Mapk1 | multiple interactions | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acetylcysteine results in increased activity of and results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acetylcysteine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [1,2,5,8-tetrahydroxy anthraquinone results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [4-(methylthio)-3-butenyl isothiocyanate results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [acacetin results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [antimony trichloride results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Arsenic analog results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Butyric Acid results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of and results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Capsaicin results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [ceric oxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Curcumin results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Daunorubicin results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [DDT results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [dihydromyricetin results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Dinitrochlorobenzene results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [dorsomorphin results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [ellipticine results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Etoposide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Fenretinide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Mercuric Chloride inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK1 protein]]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [morusin results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Quinacrine results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [sepantronium results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [shikonin results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [tetrabromobisphenol A results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Thimerosal results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Thiostrepton results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [titanium dioxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [tomentosin results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; Acetylcysteine results in increased activity of and results in increased phosphorylation of MAPK1 protein; Acetylcysteine results in increased phosphorylation of and results in increased activity of MAPK1 protein | PMID:14623829 PMID:15978937 PMID:16014620 PMID:16251475 PMID:16632126 PMID:17458902 PMID:17596522 PMID:17828457 PMID:18357586 PMID:18495191 PMID:18703135 PMID:19038359 PMID:20951154 PMID:21055460 PMID:21135414 PMID:21391979 PMID:21843585 PMID:22288910 PMID:22761781 PMID:22867088 PMID:22910795 PMID:23370007 PMID:23416263 PMID:23836369 PMID:24019090 PMID:24463199 PMID:24582688 PMID:25246272 PMID:25724548 PMID:25876056 PMID:26514923 PMID:27539140 PMID:28600122 PMID:28867437 PMID:29155359 PMID:30055241 PMID:30766661 PMID:30871965 PMID:30917517 PMID:31068539 PMID:31313457 PMID:31724279 PMID:31837377 PMID:31860779 PMID:31900833 PMID:32305283 PMID:32683294 PMID:32745510 PMID:33030807 PMID:33035517 PMID:33421718 PMID:34439521 PMID:34510229 PMID:34580807 PMID:34890707 PMID:34963561 PMID:35122928 PMID:36740148 | Mapk1 | multiple interactions | ISO | Mapk1 (Mus musculus) | 6480464 | CTD | [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in increased expression of MAPK1 mRNA]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in increased phosphorylation of MAPK1 protein]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Polystyrenes promotes the reaction [Lipopolysaccharides results in increased expression of MAPK1 mRNA]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Polystyrenes promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]; Acetylcysteine affects the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein]]; Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [[tungsten carbide co-treated with Cobalt] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Indican results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [LHB protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]; Acetylcysteine promotes the reaction [Polymyxin B inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]] | PMID:14516795 PMID:16024921 PMID:16445087 PMID:18629305 PMID:19038359 PMID:19747498 PMID:21220312 PMID:21533816 PMID:21549813 PMID:25199686 PMID:25531190 PMID:25724548 PMID:28555929 PMID:29248572 PMID:29486182 PMID:30849338 PMID:35833596 | | ||||||||||||||||||||||
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