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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:28741
Term: sodium fluoride
Definition: A metal fluoride salt with a Na(+) counterion.
Chemical ID: MESH:D012969
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1affects expressionEXP 6480464CTDSodium Fluoride affects the expression of MAPK1 protein modified formPMID:28099871
Mapk1decreases expressionEXP 6480464CTDSodium Fluoride results in decreased expression of MAPK1 proteinPMID:28099871
Mapk1increases expressionEXP 6480464CTDSodium Fluoride results in increased expression of MAPK1 proteinPMID:19900517
Mapk1increases phosphorylationEXP 6480464CTDSodium Fluoride results in increased phosphorylation of MAPK1 proteinPMID:19900517 PMID:30130557
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDSodium Fluoride results in increased phosphorylation of MAPK1 proteinPMID:19376214 PMID:25540590
Mapk1increases phosphorylationISOMapk1 (Mus musculus)6480464CTDSodium Fluoride results in increased phosphorylation of MAPK1 proteinPMID:23578390 PMID:26862884
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Sodium Fluoride results in increased phosphorylation of MAPK1 protein]; Sodium Fluoride results in increased phosphorylation of and affects the localization of MAPK1 protein; U 0126 inhibits the reaction [Sodium Fluoride results in increased phosphorylation of MAPK1 protein]PMID:19376214 PMID:30130557
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Sodium Fluoride results in increased phosphorylation of MAPK1 protein]PMID:23578390
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