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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:28216
Term: methylmercury chloride
Definition: A chlorine molecular entity that has formula CH3ClHg.
Chemical ID: MESH:C004925
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1affects expressionEXP 6480464CTDmethylmercuric chloride affects the expression of MAPK1 mRNAPMID:20864626
Mapk1decreases phosphorylationEXP 6480464CTDmethylmercuric chloride results in decreased phosphorylation of MAPK1 proteinPMID:28821999 PMID:29258870
Mapk1increases phosphorylationEXP 6480464CTDmethylmercuric chloride results in increased phosphorylation of MAPK1 proteinPMID:32061141
Mapk1multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [methylmercuric chloride results in decreased expression of and results in increased phosphorylation of MAPK1 protein]; methylmercuric chloride results in decreased expression of and results in increased phosphorylation of MAPK1 protein; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of MAPK1 protein]PMID:32061141 PMID:36813253
Mapk1decreases phosphorylationISOMapk1 (Mus musculus)6480464CTDmethylmercuric chloride results in decreased phosphorylation of MAPK1 proteinPMID:33338554
Mapk1increases phosphorylationISOMapk1 (Mus musculus)6480464CTDmethylmercuric chloride results in increased phosphorylation of MAPK1 proteinPMID:27667695
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTDLEP protein affects the reaction [methylmercuric chloride results in decreased phosphorylation of MAPK1 protein]PMID:33338554
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