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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1decreases expressionEXP 6480464CTDresveratrol results in decreased expression of MAPK1 protein modified formPMID:27093858
Mapk1decreases phosphorylationEXP 6480464CTDresveratrol results in decreased phosphorylation of MAPK1 proteinPMID:16626303
Mapk1increases phosphorylationEXP 6480464CTDresveratrol results in increased phosphorylation of MAPK1 proteinPMID:20486211 PMID:21203465
Mapk1multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of and affects the localization of MAPK1 protein]; [Resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased phosphorylation of MAPK1 protein; arginyl-glycyl-aspartic acid inhibits the reaction [Resveratrol results in increased phosphorylation of MAPK1 protein]; dorsomorphin inhibits the reaction [Resveratrol results in decreased expression of MAPK1 protein modified form]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Resveratrol promotes the reaction [MAPK1 protein binds to PTGS2 protein]]; Resveratrol inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of MAPK1 protein]; Resveratrol inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of MAPK1 protein modified form]; Resveratrol inhibits the reaction [AGT protein modified form results in increased phosphorylation of MAPK1 protein]; Resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Resveratrol inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]; Resveratrol inhibits the reaction [Hydrogen Peroxide results in increased activity of MAPK1 protein]; Resveratrol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Resveratrol inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]; Resveratrol inhibits the reaction [INS1 protein results in increased phosphorylation of MAPK1 protein]; Resveratrol inhibits the reaction [Lysophosphatidylcholines results in increased phosphorylation of MAPK1 protein]; Resveratrol inhibits the reaction [manganese chloride results in increased phosphorylation of MAPK1 protein]; Resveratrol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK1 protein]; Resveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Resveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein]; Resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of MAPK1 protein]; Resveratrol promotes the reaction [MAPK1 protein binds to PTGS2 protein]; Resveratrol results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; Resveratrol results in increased phosphorylation of and affects the localization of MAPK1 protein; Resveratrol results in increased phosphorylation of and results in increased activity of MAPK1 proteinPMID:12237323 PMID:15882976 PMID:16212921 PMID:16626303 PMID:16860989 PMID:17984113 PMID:18835240 PMID:19720069 PMID:20050970 PMID:20474069 PMID:20564508 PMID:21203465 PMID:21300041 PMID:23554738 PMID:23811825 PMID:24079413 PMID:24971582 PMID:27093858 PMID:36183783
Mapk1affects expressionISOMapk1 (Mus musculus)6480464CTDresveratrol affects the expression of MAPK1 protein modified formPMID:22878646
Mapk1affects localizationISOMAPK1 (Homo sapiens)6480464CTDresveratrol affects the localization of MAPK1 proteinPMID:18446786
Mapk1decreases activityISOMAPK1 (Homo sapiens)6480464CTDresveratrol results in decreased activity of MAPK1 proteinPMID:11408617 PMID:15698585 PMID:23921149
Mapk1decreases expressionISOMAPK1 (Homo sapiens)6480464CTDresveratrol results in decreased expression of MAPK1 proteinPMID:18089832
Mapk1decreases expressionISOMapk1 (Mus musculus)6480464CTDresveratrol results in decreased expression of MAPK1 mRNAPMID:22610192
Mapk1decreases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDresveratrol analog results in decreased phosphorylation of MAPK1 protein; resveratrol results in decreased phosphorylation of MAPK1 proteinPMID:14623829 PMID:14749477 PMID:16761963 PMID:18347188 PMID:21756928 PMID:22234583 PMID:23527233 PMID:24832111 PMID:25198200 PMID:25619392 PMID:25672876 PMID:26394120
Mapk1decreases phosphorylationISOMapk1 (Mus musculus)6480464CTDresveratrol results in decreased phosphorylation of MAPK1 proteinPMID:17675339 PMID:23525482
Mapk1increases activityISOMAPK1 (Homo sapiens)6480464CTDresveratrol results in increased activity of MAPK1 proteinPMID:18446786
Mapk1increases activityISOMapk1 (Mus musculus)6480464CTDresveratrol results in increased activity of MAPK1 proteinPMID:21679764
Mapk1increases expressionISOMAPK1 (Homo sapiens)6480464CTDresveratrol results in increased expression of MAPK1 protein modified formPMID:18446786 PMID:20133117
Mapk1increases expressionISOMapk1 (Mus musculus)6480464CTDresveratrol results in increased expression of MAPK1 protein modified formPMID:24330398
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDResveratrol results in increased phosphorylation of MAPK1 proteinPMID:16790523 PMID:16814113 PMID:17499741 PMID:21168265 PMID:21745208 PMID:22917016 PMID:23445485 PMID:23527233 PMID:25436977 PMID:25645941 PMID:29242151 PMID:31336132
Mapk1increases phosphorylationISOMapk1 (Mus musculus)6480464CTDresveratrol results in increased phosphorylation of MAPK1 proteinPMID:24125781 PMID:24449132
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol affects the localization of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased activity of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased expression of MAPK1 protein modified form]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased localization of and results in increased activity of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of MAPK1 protein]; [ITGA5 protein binds to ITGB3 protein] promotes the reaction [Resveratrol results in increased phosphorylation of MAPK1 protein]; [Resveratrol affects the phosphorylation of SRC protein] affects the reaction [sodium arsenite results in increased activity of [MAPK1 protein co-treated with MAPK3 protein]]; [Resveratrol results in decreased activity of MAPK1 protein] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] which results in decreased susceptibility to Resveratrol; AG 1879 inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; arginyl-glycyl-aspartic acid inhibits the reaction [Resveratrol results in increased phosphorylation of MAPK1 protein]; EGF protein inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK1 protein]; Fulvestrant inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; HRAS protein promotes the reaction [Resveratrol results in increased activity of MAPK1 protein]; HRAS protein promotes the reaction [Resveratrol results in increased phosphorylation of and results in increased localization of and results in increased activity of MAPK1 protein]; MAPK1 protein affects the reaction [Resveratrol results in increased expression of PRF1 protein]; midostaurin affects the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK1 protein]; PD168393 inhibits the reaction [Resveratrol results in increased phosphorylation of MAPK1 protein]; PRKCA protein affects the reaction [EGF protein inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK1 protein]]; Resveratrol affects the reaction [sodium arsenite results in increased activity of [MAPK3 protein co-treated with MAPK1 protein]]; Resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Resveratrol analog inhibits the reaction [Calcimycin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Resveratrol analog inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Resveratrol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased phosphorylation of MAPK1 protein]; Resveratrol inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; Resveratrol inhibits the reaction [ALB protein modified form results in increased phosphorylation of MAPK1 protein]; Resveratrol inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; Resveratrol inhibits the reaction [C5 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Resveratrol inhibits the reaction [Estradiol results in increased expression of MAPK1 protein modified form]; Resveratrol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Resveratrol inhibits the reaction [IL18 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; Resveratrol inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK1 protein]; Resveratrol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK1 protein]; Resveratrol inhibits the reaction [NRG1 protein alternative form results in increased phosphorylation of MAPK1 protein]; Resveratrol inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]; Resveratrol inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]; Resveratrol inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Resveratrol results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; Resveratrol results in increased activity of and results in increased phosphorylation of MAPK1 protein; Resveratrol results in increased expression of and results in increased phosphorylation of MAPK1 protein; Resveratrol results in increased phosphorylation of and results in increased activity of and affects the localization of MAPK1 protein; Resveratrol results in increased phosphorylation of and results in increased activity of MAPK1 protein; Resveratrol results in increased phosphorylation of and results in increased localization of and results in increased activity of MAPK1 protein; SB 203580 inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Staurosporine inhibits the reaction [EGF protein inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK1 protein]]; Staurosporine promotes the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of and affects the localization of MAPK1 protein]PMID:11889192 PMID:12690110 PMID:14623829 PMID:14739659 PMID:15542774 PMID:15615701 PMID:16212921 PMID:16227395 PMID:16317118 PMID:16343977 PMID:16790523 PMID:16814113 PMID:17554206 PMID:17651959 PMID:17689939 PMID:17919812 PMID:18222423 PMID:18446786 PMID:18462857 PMID:18647594 PMID:18776917 PMID:19038233 PMID:19321006 PMID:19346296 PMID:19416633 PMID:19561311 PMID:20082299 PMID:20677551 PMID:20696143 PMID:21467134 PMID:21756928 PMID:22634503 PMID:23527233 PMID:23936610 PMID:23954321 PMID:26335192 PMID:28495310 PMID:29242151 PMID:33421718
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]; MAPK1 protein promotes the reaction [resveratrol results in increased phosphorylation of and results in increased activity of TRP53 protein]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]; resveratrol inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of MAPK1 protein modified form]; resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased phosphorylation of MAPK1 protein]; resveratrol inhibits the reaction [C5 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; resveratrol inhibits the reaction [Dextran Sulfate results in increased activity of MAPK1 protein]; resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK1 protein]; resveratrol inhibits the reaction [Dinoprostone results in increased phosphorylation of MAPK1 protein]; resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]; resveratrol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein]; resveratrol promotes the reaction [Cocaine results in increased phosphorylation of MAPK1 protein]; resveratrol promotes the reaction [MAPK1 protein binds to TRP53 protein]; resveratrol results in increased phosphorylation of and results in increased activity of MAPK1 protein; wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]PMID:11245472 PMID:16322078 PMID:16474181 PMID:19346296 PMID:20155626 PMID:22363816 PMID:22952890 PMID:23499958 PMID:24333336 PMID:24682241 PMID:25234201 PMID:27093858 PMID:29486182
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