GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mapk1 | increases expression | EXP | | 6480464 | CTD | tributyltin results in increased expression of MAPK1 protein | PMID:30172001 | Mapk1 | increases phosphorylation | EXP | | 6480464 | CTD | tributyltin results in increased phosphorylation of MAPK1 protein | PMID:23743147 PMID:26873547 | Mapk1 | decreases expression | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | tributyltin results in decreased expression of MAPK1 mRNA | PMID:27678064 | Mapk1 | increases activity | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | tributyltin results in increased activity of MAPK1 protein | PMID:18989867 | Mapk1 | increases activity | ISO | Mapk1 (Mus musculus) | 6480464 | CTD | tributyltin results in increased activity of MAPK1 protein | PMID:22223438 | Mapk1 | increases phosphorylation | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | tributyltin results in increased phosphorylation of MAPK1 protein | PMID:11042092 | Mapk1 | increases phosphorylation | ISO | Mapk1 (Mus musculus) | 6480464 | CTD | tributyltin results in increased phosphorylation of MAPK1 protein | PMID:30172001 | Mapk1 | multiple interactions | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [tributyltin results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tributyltin results in increased activity of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tributyltin results in increased phosphorylation of MAPK1 protein]; [U 0126 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [tributyltin results in increased activity of MAPK1 protein]; Estradiol promotes the reaction [tributyltin results in increased expression of and results in increased phosphorylation of MAPK1 protein]; tributyltin affects the phosphorylation of and affects the activity of MAPK1 protein; tributyltin results in increased expression of and results in increased phosphorylation of MAPK1 protein; U 0126 inhibits the reaction [tributyltin results in increased activity of MAPK1 protein] | PMID:11042092 PMID:18989867 PMID:23523586 PMID:34329126 | | ||||||||||||||||||||||
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