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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:17243
Term: mono(2-ethylhexyl) phthalate
Definition: The mono(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:C016599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases phosphorylationEXP 6480464CTDmono-(2-ethylhexyl)phthalate results in increased phosphorylation of MAPK1 proteinPMID:37941498
Mapk1affects phosphorylationISOMAPK1 (Homo sapiens)6480464CTDmono-(2-ethylhexyl)phthalate affects the phosphorylation of MAPK1 proteinPMID:30810372
Mapk1decreases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDmono-(2-ethylhexyl)phthalate results in decreased phosphorylation of MAPK1 proteinPMID:35841924
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDmono-(2-ethylhexyl)phthalate results in increased phosphorylation of MAPK1 proteinPMID:28390675
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD[bisphenol A co-treated with mono-(2-ethylhexyl)phthalate] results in increased phosphorylation of MAPK1 protein; [mono-(2-ethylhexyl)phthalate co-treated with bisphenol A] inhibits the reaction [HDAC6 protein affects the phosphorylation of MAPK1 protein]; Zinc inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased phosphorylation of MAPK1 protein]PMID:34910997 PMID:35841924
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTDmono-(2-ethylhexyl)phthalate inhibits the reaction [GDNF protein results in increased phosphorylation of MAPK1 protein]PMID:22564763
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