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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:167670
Term: SCH772984
Definition: A member of the class of indazoles that is 1H-indazole substituted by pyridin-4-yl and {[(3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)pyrrolidin-3-yl]carbonyl}amino groups at positions 3 and 5, respectively. It is a potent inhibitor of mitogen-activated protein kinases ERK1 and ERK2 (IC50 = 4 and 1 nM, respectively) that exhibits anti-cancer properties.
Chemical ID: MESH:C587178
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1decreases activityEXP 6480464CTDSCH772984 results in decreased activity of MAPK1 proteinPMID:28087833
Mapk1decreases expressionEXP 6480464CTDSCH772984 results in decreased expression of MAPK1 proteinPMID:28087833
Mapk1increases phosphorylationEXP 6480464CTDSCH772984 results in increased phosphorylation of MAPK1 proteinPMID:28087833
Mapk1multiple interactionsEXP 6480464CTDSCH772984 inhibits the reaction [diphenylarsinic acid results in increased phosphorylation of MAPK1 protein]PMID:28087833
Mapk1decreases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDSCH772984 results in decreased phosphorylation of MAPK1 proteinPMID:32156566
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTDSCH772984 inhibits the reaction [3,4,5-tri-O-(E)-caffeoylquinic acid analog results in increased phosphorylation of MAPK1 protein]; SCH772984 inhibits the reaction [GPR4 protein affects the phosphorylation of MAPK1 protein]; SCH772984 inhibits the reaction [Ozone results in increased phosphorylation of MAPK1 protein]; SCH772984 inhibits the reaction [pachastrissamine analog results in increased phosphorylation of MAPK1 protein]; SCH772984 inhibits the reaction [saikosaponin D results in increased phosphorylation of and results in increased activity of MAPK1 protein]PMID:29925859 PMID:32156566 PMID:32822868 PMID:33161135 PMID:35123989
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