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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:15365
Term: acetylsalicylic acid
Definition: A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Chemical ID: MESH:D001241
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1decreases expressionISOMAPK1 (Homo sapiens)6480464CTDAspirin results in decreased expression of MAPK1 protein modified formPMID:15447849
Mapk1increases activityISOMAPK1 (Homo sapiens)6480464CTDAspirin results in increased activity of MAPK1 proteinPMID:21617849
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTDAspirin inhibits the reaction [HGF results in increased activity of MAPK1 protein]; Aspirin inhibits the reaction [HMGB1 protein results in increased phosphorylation of MAPK1 protein]; Aspirin results in decreased phosphorylation of and results in decreased activity of MAPK1 proteinPMID:11981761 PMID:20116423 PMID:34755645
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTDAspirin results in decreased phosphorylation of and results in decreased activity of MAPK1 proteinPMID:10993886
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