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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70488
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tfrc
Name: transferrin receptor
Acc ID: CHEBI:4911
Term: etoposide
Definition: A furonaphthodioxole that has formula C29H32O13.
Chemical ID: MESH:D005047
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tfrcdecreases expressionISOTFRC (Homo sapiens)6480464CTDEtoposide results in decreased expression of TFRC mRNA; Etoposide results in decreased expression of TFRC proteinPMID:33969609
Tfrcmultiple interactionsISOTFRC (Homo sapiens)6480464CTD1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Etoposide results in decreased expression of TFRC protein]PMID:33969609
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