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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70069
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcl2
Name: C-X-C motif chemokine ligand 2
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl2multiple interactionsEXP 6480464CTDDexamethasone inhibits the reaction [Ozone results in increased expression of CXCL2 mRNA]; Dexamethasone promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CXCL2 mRNA]PMID:18590720 PMID:7737418
Cxcl2decreases expressionISOCXCL2 (Homo sapiens)6480464CTDDexamethasone results in decreased expression of CXCL2 mRNAPMID:25047013
Cxcl2increases expressionISOCxcl2 (Mus musculus)6480464CTDDexamethasone results in increased expression of CXCL2 mRNAPMID:25900201
Cxcl2multiple interactionsISOCxcl2 (Mus musculus)6480464CTD[Cyclophosphamide co-treated with Dexamethasone] inhibits the reaction [Paraquat results in increased expression of CXCL2 mRNA]; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL2 mRNA; Amiodarone inhibits the reaction [Dexamethasone results in increased expression of CXCL2 mRNA]; Dexamethasone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL2 protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL2 protein]; Dexamethasone inhibits the reaction [Ozone results in increased expression of CXCL2 protein]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL2 mRNA]PMID:14754758 PMID:22154906 PMID:23503329 PMID:25900201 PMID:30849337 PMID:36031164
Cxcl2multiple interactionsISOCXCL2 (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CXCL2 mRNA; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CXCL2 mRNA; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of CXCL2 mRNAPMID:28628672
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