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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70069
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcl2
Name: C-X-C motif chemokine ligand 2
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl2multiple interactionsEXP 6480464CTDCurcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased secretion of CXCL2 protein]PMID:18001810
Cxcl2decreases expressionISOCXCL2 (Homo sapiens)6480464CTDCurcumin results in decreased expression of CXCL2 mRNA; Curcumin results in decreased expression of CXCL2 proteinPMID:17999991
Cxcl2multiple interactionsISOCxcl2 (Mus musculus)6480464CTDCurcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CXCL2 mRNA]PMID:18200517 PMID:27194111
Cxcl2multiple interactionsISOCXCL2 (Homo sapiens)6480464CTDNFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL2 mRNA]PMID:17999991
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