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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70069
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcl2
Name: C-X-C motif chemokine ligand 2
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl2affects expressionISOCxcl2 (Mus musculus)6480464CTDCisplatin affects the expression of CXCL2 mRNAPMID:21151649
Cxcl2decreases expressionISOCXCL2 (Homo sapiens)6480464CTDCisplatin results in decreased expression of CXCL2 mRNAPMID:27392435
Cxcl2increases expressionISOCxcl2 (Mus musculus)6480464CTDCisplatin results in increased expression of CXCL2 mRNA; Cisplatin results in increased expression of CXCL2 proteinPMID:15814532 PMID:20702592 PMID:20844023
Cxcl2increases response to substanceISOCXCL2 (Homo sapiens)6480464CTDCXCL2 protein results in increased susceptibility to CisplatinPMID:21271225
Cxcl2multiple interactionsISOCxcl2 (Mus musculus)6480464CTD[Cisplatin co-treated with TNF protein] results in increased expression of CXCL2 mRNA; pirinixic acid inhibits the reaction [Cisplatin results in increased expression of CXCL2 mRNA]PMID:15814532 PMID:23103562
Cxcl2multiple interactionsISOCXCL2 (Homo sapiens)6480464CTD[Cisplatin co-treated with jinfukang] results in decreased expression of CXCL2 mRNA; CXCL2 protein promotes the reaction [Cisplatin results in increased activity of CASP9 protein]PMID:21271225 PMID:27392435
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