Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70069
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcl2
Name: C-X-C motif chemokine ligand 2
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl2increases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of CXCL2 mRNA; Lipopolysaccharides results in increased expression of CXCL2 proteinPMID:16401727 PMID:16415329 PMID:21362633 PMID:23568217 PMID:24333275 PMID:33727093
Cxcl2increases secretionEXP 6480464CTDLipopolysaccharides results in increased secretion of CXCL2 proteinPMID:21362633
Cxcl2multiple interactionsEXP 6480464CTD[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of CXCL2 mRNA; [Ranitidine co-treated with Lipopolysaccharides] results in increased expression of CXCL2 protein; alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA]; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of CXCL2 mRNA]; Heparin inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of CXCL2 protein]]; Ibuprofen inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 protein]; Lipopolysaccharides promotes the reaction [RELA protein binds to CXCL2 promoter]; oxymatrine inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to CXCL2 promoter]]; oxymatrine inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA]; Pentoxifylline inhibits the reaction [[Ranitidine co-treated with Lipopolysaccharides] results in increased expression of CXCL2 protein]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of CXCL2 protein]PMID:11545620 PMID:16401727 PMID:16415329 PMID:17698507 PMID:23568217 PMID:24333275
Cxcl2increases expressionISOCxcl2 (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of CXCL2 mRNA; Lipopolysaccharides results in increased expression of CXCL2 proteinPMID:10027076 PMID:10975854 PMID:11605937 PMID:11818323 PMID:12057914 PMID:12604170 PMID:15371095 PMID:18653653 PMID:21356202 PMID:21461237 PMID:21607289 PMID:21777521 PMID:22154906 PMID:23099361 PMID:23999131 PMID:26582142 PMID:27339419 PMID:32345916
Cxcl2increases expressionISOCXCL2 (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of CXCL2 mRNA; Lipopolysaccharides results in increased expression of CXCL2 proteinPMID:10718115 PMID:18684396 PMID:35811015
Cxcl2increases secretionISOCxcl2 (Mus musculus)6480464CTDLipopolysaccharides results in increased secretion of CXCL2 proteinPMID:15593098 PMID:18523137 PMID:22154906 PMID:32800949
Cxcl2multiple interactionsISOCxcl2 (Mus musculus)6480464CTD[Lipopolysaccharides results in increased abundance of Prostaglandin D2] which results in increased expression of CXCL2 protein; [pirinixic acid binds to and results in increased activity of PPARA protein] inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 protein]; [Shiga Toxin 2 co-treated with Lipopolysaccharides] results in increased expression of CXCL2 mRNA; bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CXCL2 protein]; Cathelicidins inhibits the reaction [[Shiga Toxin 2 co-treated with Lipopolysaccharides] results in increased expression of CXCL2 mRNA]; cordycepin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA]; deoxynivalenol promotes the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL2 protein]; Dobutamine inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA]; dopexamine inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA]; Lipopolysaccharides results in increased expression of and results in increased secretion of CXCL2 protein; Oligopeptides inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA]; Oligopeptides inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL2 protein]; P2RY6 gene affects the reaction [Uridine Diphosphate promotes the reaction [Lipopolysaccharides results in increased secretion of CXCL2 protein]]; PARP1 protein affects the reaction [Lipopolysaccharides results in increased expression of CXCL2 protein]; PTGDR protein promotes the reaction [[Lipopolysaccharides results in increased abundance of Prostaglandin D2] which results in increased expression of CXCL2 protein]; Quercetin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 protein]; Tetrachlorodibenzodioxin promotes the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA]; Uridine Diphosphate promotes the reaction [Lipopolysaccharides results in increased secretion of CXCL2 protein]PMID:11605937 PMID:11818323 PMID:12604170 PMID:18523137 PMID:18653653 PMID:21166666 PMID:21607289 PMID:21731756 PMID:22154906 PMID:23099361 PMID:23999131 PMID:26918785
Cxcl2multiple interactionsISOCXCL2 (Homo sapiens)6480464CTD[S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of CXCL2 mRNA; [S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in increased expression of CXCL2 mRNA; ANXA1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA]PMID:21777521 PMID:35811015
Go Back to source page   Continue to Ontology report