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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70069
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcl2
Name: C-X-C motif chemokine ligand 2
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl2increases expressionEXP 6480464CTDOxygen deficiency results in increased expression of CXCL2 mRNAPMID:26476374
Cxcl2multiple interactionsEXP 6480464CTD[Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in increased expression of CXCL2 mRNA; Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of CXCL2 mRNA]PMID:26476374 PMID:33729688
Cxcl2increases expressionISOCxcl2 (Mus musculus)6480464CTDOxygen results in increased expression of CXCL2 mRNA; Oxygen results in increased expression of CXCL2 proteinPMID:10027076 PMID:10781441 PMID:11498801 PMID:22363622
Cxcl2multiple interactionsISOCxcl2 (Mus musculus)6480464CTD[NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of CXCL2 mRNA; [POSTN gene mutant form results in decreased susceptibility to Oxygen] which results in decreased expression of CXCL2 mRNA; POSTN gene mutant form inhibits the reaction [Oxygen results in increased expression of CXCL2 mRNA]; SCGB1A1 protein affects the reaction [Oxygen results in increased expression of CXCL2 mRNA]PMID:10027076 PMID:22363622 PMID:30529165
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