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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69427
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pdk1
Name: pyruvate dehydrogenase kinase 1
Acc ID: CHEBI:94186
Term: tubastatin A
Definition: A pyridoindole that is 1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indole which is substituted on the tetrahydropyridine nitrogen by a methyl group and on the indole nitrogen by a p-[N-(hydroxy)aminocarbonyl]benzyl group. It is a histone deacetylase 6 (HDAC6) inhibitor that is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold).
Chemical ID: MESH:C553587
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pdk1multiple interactionsISOPdk1 (Mus musculus)6480464CTDtubastatin A affects the reaction [PDK1 protein affects the abundance of Cyclic AMP]PMID:28887310
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