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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Srebf1decreases expressionISOSREBF1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of SREBF1 mRNA; Arsenic Trioxide results in decreased expression of SREBF1 proteinPMID:20339114 PMID:20458559 PMID:27622732
Srebf1decreases expressionISOSrebf1 (Mus musculus)6480464CTDArsenic Trioxide results in decreased expression of SREBF1 mRNA; Arsenic Trioxide results in decreased expression of SREBF1 proteinPMID:20339114 PMID:30237538
Srebf1multiple interactionsISOSREBF1 (Homo sapiens)6480464CTD[22-hydroxycholesterol co-treated with Alitretinoin] inhibits the reaction [Arsenic Trioxide results in decreased expression of SREBF1 protein]PMID:27622732
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