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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69366
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ldhc
Name: lactate dehydrogenase C
Acc ID: CHEBI:15891
Term: taurine
Definition: An amino sulfonic acid that is the 2-amino derivative of ethanesulfonic acid. It is a naturally occurring amino acid derived from methionine and cysteine metabolism. An abundant component of fish- and meat-based foods, it has been used as an oral supplement in the treatment of disorders such as cystic fibrosis and hypertension.
Chemical ID: MESH:D013654
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ldhcincreases activityEXP 6480464CTDTaurine results in increased activity of LDHC proteinPMID:33548410
Ldhcmultiple interactionsEXP 6480464CTD[Taurine co-treated with coenzyme Q10] inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]; [Taurine co-treated with coenzyme Q10] results in increased activity of LDHC protein; Taurine inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]; Taurine inhibits the reaction [Nandrolone Decanoate results in decreased activity of LDHC protein]PMID:25542992 PMID:33548410
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