GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cdkn1a | increases expression | EXP | | 6480464 | CTD | Glucose results in increased expression of CDKN1A mRNA; Glucose results in increased expression of CDKN1A protein | PMID:22561310 PMID:27652271 | Cdkn1a | multiple interactions | EXP | | 6480464 | CTD | Glucose promotes the reaction [SETD7 protein binds to CDKN1A promoter]; NAD inhibits the reaction [Glucose results in increased expression of CDKN1A protein]; Niacinamide inhibits the reaction [Sirolimus inhibits the reaction [Glucose results in increased expression of CDKN1A protein]]; resveratrol inhibits the reaction [Glucose results in increased expression of CDKN1A protein]; Sirolimus inhibits the reaction [Glucose results in increased expression of CDKN1A protein]; SIRT1 protein promotes the reaction [NAD inhibits the reaction [Glucose results in increased expression of CDKN1A protein]]; SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of CDKN1A protein]]; SIRT1 protein promotes the reaction [Sirolimus inhibits the reaction [Glucose results in increased expression of CDKN1A protein]]; TGFB1 protein promotes the reaction [Glucose promotes the reaction [SETD7 protein binds to CDKN1A promoter]]; TGFB1 protein promotes the reaction [Glucose results in increased expression of CDKN1A mRNA] | PMID:22561310 PMID:27652271 | Cdkn1a | decreases expression | ISO | CDKN1A (Homo sapiens) | 6480464 | CTD | Glucose results in decreased expression of CDKN1A protein | PMID:33992720 | Cdkn1a | increases expression | ISO | Cdkn1a (Mus musculus) | 6480464 | CTD | Glucose results in increased expression of CDKN1A mRNA | PMID:17178593 | Cdkn1a | increases expression | ISO | CDKN1A (Homo sapiens) | 6480464 | CTD | Glucose results in increased expression of CDKN1A mRNA; Glucose results in increased expression of CDKN1A protein | PMID:27049278 PMID:35264022 PMID:38000455 | Cdkn1a | multiple interactions | ISO | CDKN1A (Homo sapiens) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in increased expression of CDKN1A mRNA]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in increased expression of CDKN1A protein]]; [Glucose co-treated with Deferoxamine] results in increased expression of CDKN1A mRNA; [Palmitic Acid co-treated with Glucose] results in increased expression of CDKN1A mRNA; Fluorometholone inhibits the reaction [Glucose results in increased expression of CDKN1A protein]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of CDKN1A mRNA]; Melatonin inhibits the reaction [Glucose results in increased expression of CDKN1A protein]; Phytic Acid inhibits the reaction [Glucose results in increased expression of CDKN1A mRNA]; Phytic Acid inhibits the reaction [Glucose results in increased expression of CDKN1A protein]; Resveratrol inhibits the reaction [Glucose results in increased expression of CDKN1A mRNA]; SIRT1 protein mutant form inhibits the reaction [[Palmitic Acid co-treated with Glucose] results in increased expression of CDKN1A mRNA]; TAS1R1 protein affects the reaction [Glucose results in decreased expression of CDKN1A protein] | PMID:24451382 PMID:27049278 PMID:33962019 PMID:33992720 PMID:35264022 PMID:38000455 | | ||||||||||||||||||||||
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