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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69328
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin-dependent kinase inhibitor 1A
Acc ID: CHEBI:10022
Term: deoxynivalenol
Definition: A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination.
Chemical ID: MESH:C007262
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1adecreases degradationISOCDKN1A (Homo sapiens)6480464CTDdeoxynivalenol results in decreased degradation of CDKN1A mRNAPMID:18006205
Cdkn1aincreases expressionISOCdkn1a (Mus musculus)6480464CTDdeoxynivalenol results in increased expression of CDKN1A mRNAPMID:22454431
Cdkn1aincreases expressionISOCDKN1A (Homo sapiens)6480464CTDdeoxynivalenol results in increased expression of CDKN1A mRNA; deoxynivalenol results in increased expression of CDKN1A proteinPMID:18006205 PMID:30169763 PMID:30286430 PMID:31863870 PMID:34677630
Cdkn1amultiple interactionsISOCDKN1A (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in increased expression of CDKN1A mRNA]; EGR1 protein affects the reaction [deoxynivalenol results in increased expression of CDKN1A protein]; U 0126 inhibits the reaction [deoxynivalenol results in decreased degradation of CDKN1A mRNA]PMID:18006205 PMID:30286430 PMID:34677630
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