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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69325
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp11a1
Name: cytochrome P450, family 11, subfamily a, polypeptide 1
Acc ID: CHEBI:6908
Term: trichlorfon
Definition: A phosphonic ester that is dimethyl phosphonate in which the hydrogen atom attched to the phosphorous is substituted by a 2,2,2-trichloro-1-hydroxyethyl group.
Chemical ID: MESH:D014236
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp11a1decreases activityEXP 6480464CTDTrichlorfon results in decreased activity of CYP11A1 proteinPMID:37419161
Cyp11a1decreases expressionEXP 6480464CTDTrichlorfon results in decreased expression of CYP11A1 mRNAPMID:37419161
Cyp11a1decreases activityISOCyp11a1 (Mus musculus)6480464CTDTrichlorfon results in decreased activity of CYP11A1 proteinPMID:17350742
Cyp11a1decreases expressionISOCyp11a1 (Mus musculus)6480464CTDTrichlorfon results in decreased expression of CYP11A1 mRNA; Trichlorfon results in decreased expression of CYP11A1 proteinPMID:17350742
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