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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69325
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp11a1
Name: cytochrome P450, family 11, subfamily a, polypeptide 1
Acc ID: CHEBI:4042
Term: cypermethrin
Definition: A carboxylic ester resulting from the formal condensation between 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid and the alcoholic hydroxy group of hydroxy(3-phenoxyphenyl)acetonitrile.
Chemical ID: MESH:C017160
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp11a1decreases expressionEXP 6480464CTDcypermethrin results in decreased expression of CYP11A1 mRNA; cypermethrin results in decreased expression of CYP11A1 proteinPMID:34794910 PMID:35102696
Cyp11a1increases expressionEXP 6480464CTDcypermethrin results in increased expression of CYP11A1 mRNAPMID:35605701
Cyp11a1multiple interactionsEXP 6480464CTD[Allethrins co-treated with cyhalothrin co-treated with cypermethrin co-treated with decamethrin co-treated with fenvalerate] results in increased expression of CYP11A1 mRNA; [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in increased expression of CYP11A1 mRNA; [fenvalerate co-treated with Allethrins co-treated with cypermethrin co-treated with decamethrin co-treated with cyhalothrin] results in increased expression of CYP11A1 mRNA; MIR140 mRNA affects the reaction [cypermethrin results in decreased expression of CYP11A1 protein]; SF1 protein inhibits the reaction [cypermethrin results in decreased expression of CYP11A1 protein]PMID:33051911 PMID:33396045 PMID:34794910 PMID:34896426 PMID:36053783
Cyp11a1decreases expressionISOCyp11a1 (Mus musculus)6480464CTDcypermethrin results in decreased expression of CYP11A1 mRNA; cypermethrin results in decreased expression of CYP11A1 proteinPMID:20131380 PMID:21560301 PMID:24810582 PMID:34794910
Cyp11a1increases expressionISOCyp11a1 (Mus musculus)6480464CTDcypermethrin results in increased expression of CYP11A1 mRNAPMID:28731686 PMID:35931855
Cyp11a1multiple interactionsISOCyp11a1 (Mus musculus)6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [cypermethrin results in increased expression of CYP11A1 mRNA]; Egtazic Acid inhibits the reaction [cypermethrin results in increased expression of CYP11A1 mRNA]; Nimodipine inhibits the reaction [cypermethrin results in increased expression of CYP11A1 mRNA]PMID:28731686 PMID:35931855
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