GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp11a1 | affects activity | EXP | | 6480464 | CTD | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the activity of CYP11A1 protein | PMID:15336722 | Cyp11a1 | decreases activity | EXP | | 6480464 | CTD | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased activity of CYP11A1 protein | PMID:16199348 PMID:18065196 PMID:21664964 | Cyp11a1 | decreases expression | EXP | | 6480464 | CTD | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased expression of CYP11A1 mRNA | PMID:10684797 | Cyp11a1 | multiple interactions | EXP | | 6480464 | CTD | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of CYP11A1 protein]; 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [CGB3 protein results in increased activity of CYP11A1 protein]; 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]; [2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased activity of CYP11A1 protein] which results in decreased chemical synthesis of Progesterone | PMID:16737795 PMID:19414516 PMID:21664964 | | ||||||||||||||||||||||
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