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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69325
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp11a1
Name: cytochrome P450, family 11, subfamily a, polypeptide 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp11a1affects expressionEXP 6480464CTDbisphenol A affects the expression of CYP11A1 mRNAPMID:18191889
Cyp11a1decreases expressionEXP 6480464CTDbisphenol A analog results in decreased expression of CYP11A1 mRNA; bisphenol A analog results in decreased expression of CYP11A1 protein; bisphenol A results in decreased expression of CYP11A1 mRNA; bisphenol A results in decreased expression of CYP11A1 proteinPMID:15901920 PMID:20144698 PMID:25181051 PMID:30557795 PMID:35427877
Cyp11a1increases expressionEXP 6480464CTDbisphenol A analog results in increased expression of CYP11A1 mRNA; bisphenol A analog results in increased expression of CYP11A1 protein; bisphenol A results in increased expression of CYP11A1 mRNA; bisphenol A results in increased expression of CYP11A1 proteinPMID:23528252 PMID:26209791 PMID:28859904 PMID:29524480 PMID:34973380 PMID:36214340
Cyp11a1multiple interactionsEXP 6480464CTD[bisphenol A affects the expression of CYP11A1 mRNA] which affects the abundance of Progesterone; [bisphenol A affects the expression of CYP11A1 mRNA] which affects the abundance of TestosteronePMID:18191889
Cyp11a1affects expressionISOCyp11a1 (Mus musculus)6480464CTDbisphenol A affects the expression of CYP11A1 mRNA; bisphenol A affects the expression of CYP11A1 proteinPMID:21182934 PMID:28393075
Cyp11a1decreases expressionISOCYP11A1 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of CYP11A1 mRNA; bisphenol A results in decreased expression of CYP11A1 proteinPMID:21273127 PMID:26751127 PMID:27112698 PMID:29228121 PMID:31675489
Cyp11a1decreases expressionISOCyp11a1 (Mus musculus)6480464CTDbisphenol A results in decreased expression of CYP11A1; bisphenol A results in decreased expression of CYP11A1 mRNAPMID:20956811 PMID:23707772 PMID:24024361 PMID:26975478 PMID:28970132 PMID:30675821 PMID:31263496 PMID:33297044 PMID:36966614
Cyp11a1increases expressionISOCYP11A1 (Homo sapiens)6480464CTDbisphenol A results in increased expression of CYP11A1 mRNA; bisphenol A results in increased expression of CYP11A1 proteinPMID:34537452
Cyp11a1increases expressionISOCyp11a1 (Mus musculus)6480464CTDbisphenol A results in increased expression of CYP11A1 mRNA; bisphenol A results in increased expression of CYP11A1 proteinPMID:12021184 PMID:21123812 PMID:24014645 PMID:26063408 PMID:26209791 PMID:28697429 PMID:30196065 PMID:31132128
Cyp11a1increases methylationISOCYP11A1 (Homo sapiens)6480464CTDbisphenol A results in increased methylation of CYP11A1 genePMID:31601247
Cyp11a1multiple interactionsISOCYP11A1 (Homo sapiens)6480464CTDFulvestrant inhibits the reaction [bisphenol A results in increased expression of CYP11A1 mRNA]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of CYP11A1 protein]; U 0126 inhibits the reaction [bisphenol A results in decreased expression of CYP11A1 mRNA]PMID:29228121 PMID:34537452
Cyp11a1multiple interactionsISOCyp11a1 (Mus musculus)6480464CTD[diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3,5,6-trichloro-2-pyridinol co-treated with 3-phenoxybenzoic acid co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of CYP11A1 mRNA; bisphenol A deficiency inhibits the reaction [bisphenol A results in decreased expression of CYP11A1 mRNA]; Flavonoids inhibits the reaction [bisphenol A results in decreased expression of CYP11A1 mRNA]; pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of CYP11A1 mRNA]; pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of CYP11A1 protein]PMID:23707772 PMID:26209791 PMID:28697429 PMID:32518293 PMID:36966614
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