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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69325
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp11a1
Name: cytochrome P450, family 11, subfamily a, polypeptide 1
Acc ID: CHEBI:28384
Term: vitamin K
Definition: Any member of a group of fat-soluble 2-methyl-1,4-napthoquinones that exhibit biological activity against vitamin K deficiency. Vitamin K is required for the synthesis of prothrombin and certain other blood coagulation factors.
Chemical ID: MESH:D014812
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp11a1affects expressionEXP 6480464CTDVitamin K affects the expression of CYP11A1 mRNAPMID:16844298
Cyp11a1decreases expressionEXP 6480464CTDVitamin K deficiency results in decreased expression of CYP11A1 mRNA; Vitamin K deficiency results in decreased expression of CYP11A1 proteinPMID:21894328
Cyp11a1multiple interactionsEXP 6480464CTDLipopolysaccharides promotes the reaction [Vitamin K deficiency results in decreased expression of CYP11A1 mRNA]; Lipopolysaccharides promotes the reaction [Vitamin K deficiency results in decreased expression of CYP11A1 protein]PMID:21894328
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