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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69325
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp11a1
Name: cytochrome P450, family 11, subfamily a, polypeptide 1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp11a1decreases expressionEXP 6480464CTDresveratrol results in decreased expression of CYP11A1 mRNAPMID:24524197
Cyp11a1increases expressionEXP 6480464CTDresveratrol results in increased expression of CYP11A1 mRNAPMID:26348076
Cyp11a1multiple interactionsEXP 6480464CTD[Simvastatin co-treated with resveratrol] results in decreased expression of CYP11A1 mRNA; resveratrol inhibits the reaction [Fluoxetine results in decreased expression of CYP11A1 mRNA]PMID:24524197 PMID:26348076
Cyp11a1decreases acetylationISOCYP11A1 (Homo sapiens)6480464CTDresveratrol results in decreased acetylation of CYP11A1 proteinPMID:22585829
Cyp11a1increases expressionISOCYP11A1 (Homo sapiens)6480464CTDresveratrol results in increased expression of CYP11A1 proteinPMID:22585829
Cyp11a1multiple interactionsISOCYP11A1 (Homo sapiens)6480464CTDSIRT3 protein affects the reaction [resveratrol results in decreased acetylation of CYP11A1 protein]; SIRT3 protein affects the reaction [resveratrol results in increased expression of CYP11A1 protein]; SIRT5 protein affects the reaction [resveratrol results in decreased acetylation of CYP11A1 protein]; SIRT5 protein affects the reaction [resveratrol results in increased expression of CYP11A1 protein]PMID:22585829
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