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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69325
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp11a1
Name: cytochrome P450, family 11, subfamily a, polypeptide 1
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp11a1decreases activityEXP 6480464CTDNicotine results in decreased activity of CYP11A1 proteinPMID:28986172
Cyp11a1decreases expressionEXP 6480464CTDNicotine results in decreased expression of CYP11A1 mRNA; Nicotine results in decreased expression of CYP11A1 proteinPMID:22265867 PMID:28986172 PMID:31846720
Cyp11a1decreases expressionISOCYP11A1 (Homo sapiens)6480464CTDNicotine results in decreased expression of CYP11A1 mRNA; Nicotine results in decreased expression of CYP11A1 proteinPMID:21971485 PMID:24709674 PMID:30959089
Cyp11a1decreases expressionISOCyp11a1 (Mus musculus)6480464CTDNicotine results in decreased expression of CYP11A1 mRNA; Nicotine results in decreased expression of CYP11A1 proteinPMID:31846720
Cyp11a1multiple interactionsISOCyp11a1 (Mus musculus)6480464CTD[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CYP11A1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP11A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 protein]PMID:20230807 PMID:31846720
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