GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp11a1 | decreases activity | EXP | | 6480464 | CTD | Nicotine results in decreased activity of CYP11A1 protein | PMID:28986172 | Cyp11a1 | decreases expression | EXP | | 6480464 | CTD | Nicotine results in decreased expression of CYP11A1 mRNA; Nicotine results in decreased expression of CYP11A1 protein | PMID:22265867 PMID:28986172 PMID:31846720 | Cyp11a1 | decreases expression | ISO | CYP11A1 (Homo sapiens) | 6480464 | CTD | Nicotine results in decreased expression of CYP11A1 mRNA; Nicotine results in decreased expression of CYP11A1 protein | PMID:21971485 PMID:24709674 PMID:30959089 | Cyp11a1 | decreases expression | ISO | Cyp11a1 (Mus musculus) | 6480464 | CTD | Nicotine results in decreased expression of CYP11A1 mRNA; Nicotine results in decreased expression of CYP11A1 protein | PMID:31846720 | Cyp11a1 | multiple interactions | ISO | Cyp11a1 (Mus musculus) | 6480464 | CTD | [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CYP11A1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP11A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 protein] | PMID:20230807 PMID:31846720 | |
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