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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69325
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp11a1
Name: cytochrome P450, family 11, subfamily a, polypeptide 1
Acc ID: CHEBI:17347
Term: testosterone
Definition: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..
Chemical ID: MESH:D013739
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp11a1increases expressionEXP 6480464CTDTestosterone results in increased expression of CYP11A1 mRNA; Testosterone results in increased expression of CYP11A1 proteinPMID:21273442
Cyp11a1multiple interactionsEXP 6480464CTD[bisphenol A affects the expression of CYP11A1 mRNA] which affects the abundance of Testosterone; AR mutant form inhibits the reaction [Testosterone results in increased expression of CYP11A1 protein]; bicalutamide inhibits the reaction [Testosterone results in increased expression of CYP11A1 protein]; Finasteride promotes the reaction [Testosterone results in increased expression of CYP11A1 mRNA]; formestane promotes the reaction [Testosterone results in increased expression of CYP11A1 mRNA]; Testosterone promotes the reaction [FSHB results in increased expression of CYP11A1 mRNA]PMID:18191889 PMID:21273442
Cyp11a1affects chemical synthesisISOCyp11a1 (Mus musculus)6480464CTDCYP11A1 protein affects the chemical synthesis of TestosteronePMID:15932923
Cyp11a1decreases expressionISOCYP11A1 (Homo sapiens)6480464CTDTestosterone results in decreased expression of CYP11A1 mRNAPMID:21880219
Cyp11a1increases expressionISOCYP11A1 (Homo sapiens)6480464CTDTestosterone results in increased expression of CYP11A1 mRNAPMID:21592394 PMID:33359661
Cyp11a1multiple interactionsISOCYP11A1 (Homo sapiens)6480464CTD[FSHB protein co-treated with Testosterone] results in increased expression of CYP11A1 mRNA; [Testosterone co-treated with Calcitriol] results in increased expression of CYP11A1 mRNAPMID:18535249 PMID:21592394
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