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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69325
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp11a1
Name: cytochrome P450, family 11, subfamily a, polypeptide 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp11a1decreases expressionEXP 6480464CTDLipopolysaccharides results in decreased expression of CYP11A1 mRNA; Lipopolysaccharides results in decreased expression of CYP11A1 proteinPMID:21894328
Cyp11a1multiple interactionsEXP 6480464CTDLipopolysaccharides promotes the reaction [Vitamin K deficiency results in decreased expression of CYP11A1 mRNA]; Lipopolysaccharides promotes the reaction [Vitamin K deficiency results in decreased expression of CYP11A1 protein]PMID:21894328
Cyp11a1increases expressionISOCYP11A1 (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of CYP11A1 mRNAPMID:36774801
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