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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69325
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp11a1
Name: cytochrome P450, family 11, subfamily a, polypeptide 1
Acc ID: CHEBI:132612
Term: monobenzyl phthalate
Definition: A phthalic acid monoester resulting from the formal condensation of one of the carboxy groups of phthalic acid with the hydroxy group of benzyl alcohol. It is a major metabolite of the plasticiser butyl benzyl phthalate (BBP).
Chemical ID: MESH:C103325
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp11a1affects expressionISOCYP11A1 (Homo sapiens)6480464CTDmono-benzyl phthalate affects the expression of CYP11A1 mRNAPMID:28381288
Cyp11a1increases expressionISOCYP11A1 (Homo sapiens)6480464CTDmono-benzyl phthalate results in increased expression of CYP11A1 mRNAPMID:29089286
Cyp11a1multiple interactionsISOCyp11a1 (Mus musculus)6480464CTD[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CYP11A1 mRNAPMID:31884101
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