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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69298
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Enpp2
Name: ectonucleotide pyrophosphatase/phosphodiesterase 2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Enpp2affects expressionEXP 6480464CTDbisphenol A affects the expression of ENPP2 mRNAPMID:25181051
Enpp2decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of ENPP2 mRNAPMID:12075121 PMID:30816183 PMID:34947998
Enpp2increases expressionEXP 6480464CTDbisphenol A results in increased expression of ENPP2 mRNAPMID:32145629 PMID:33296240
Enpp2multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Testosterone] results in decreased expression of ENPP2 mRNAPMID:26496021
Enpp2decreases expressionISOENPP2 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of ENPP2 mRNAPMID:31715268
Enpp2increases expressionISOENPP2 (Homo sapiens)6480464CTDbisphenol A results in increased expression of ENPP2 mRNAPMID:29275510
Enpp2increases expressionISOEnpp2 (Mus musculus)6480464CTDbisphenol A results in increased expression of ENPP2 mRNA; bisphenol A results in increased expression of ENPP2 proteinPMID:30951980 PMID:32926169
Enpp2multiple interactionsISOENPP2 (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ENPP2 mRNAPMID:28628672
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