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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69250
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Wnt5a
Name: Wnt family member 5A
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Wnt5amultiple interactionsEXP 150530464RGD5-fluorouracil inhibits the reaction [N-methyl-N-nitrosourea increases expression of Wnt5a mRNA in colon] 
Wnt5aincreases expressionISOWNT5A (Homo sapiens)6480464CTDFluorouracil results in increased expression of WNT5A mRNAPMID:31711903
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